| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50241871 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670926 (CHEMBL4020955) |
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| IC50 | 8.1±n/a nM |
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| Citation |  Fujimoto, J; Hirayama, T; Hirata, Y; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential. Bioorg Med Chem25:3018-3033 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50241871 |
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| n/a |
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| Name | BDBM50241871 |
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| Synonyms: | CHEMBL4087219 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N4O3S |
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| Mol. Mass. | 436.527 |
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| SMILES | COc1ncc(s1)-c1ccncc1\C=C\C(=O)Nc1ccc(CN2CCOCC2)cc1 |
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| Structure | 
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