| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50003057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54094 (CHEMBL668425) |
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| IC50 | >95000±n/a nM |
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| Citation |  Gangjee, A; Patel, J; Kisliuk, RL; Gaumont, Y 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. J Med Chem35:3678-85 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
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|
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| BDBM50003057 |
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| n/a |
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| Name | BDBM50003057 |
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| Synonyms: | 7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one | CHEMBL122959 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13N5O |
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| Mol. Mass. | 243.2645 |
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| SMILES | Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21 |
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| Structure | 
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