| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional purine biosynthesis protein ATIC |
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| Ligand | BDBM50003058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_28407 |
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| IC50 | 17000±n/a nM |
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| Citation |  Gangjee, A; Patel, J; Kisliuk, RL; Gaumont, Y 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities. J Med Chem35:3678-85 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional purine biosynthesis protein ATIC |
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| Name: | Bifunctional purine biosynthesis protein ATIC |
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| Synonyms: | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase | AICAR Tfase | AICAR transformylase | ATIC | Aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) | Bifunctional purine biosynthesis protein PURH | IMP Cyclohydrolase (IMPCH) | IMP cyclohydrolase | IMP synthetase | Inosinicase | PUR9_HUMAN | PURH | Phosphoribosylaminoimidazolecarboxamide formyltransferase | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Protein |
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| Mol. Mass.: | 64616.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31939 |
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| Residue: | 592 |
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| Sequence: | MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
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| BDBM50003058 |
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| n/a |
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| Name | BDBM50003058 |
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| Synonyms: | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-2-yl)-benzoylamino]-pentanedioic acid | CHEMBL331208 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N6O6 |
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| Mol. Mass. | 450.4042 |
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| SMILES | Nc1nc(O)c2c3cn(cc3cnc2n1)-c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
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| Structure | 
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