Reaction Details |
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Target | Sucrase-isomaltase |
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Ligand | BDBM18355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1672825 (CHEMBL4022854) |
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IC50 | 1500±n/a nM |
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Citation | D'Alonzo, D; De Fenza, M; Porto, C; Iacono, R; Huebecker, M; Cobucci-Ponzano, B; Priestman, DA; Platt, F; Parenti, G; Moracci, M; Palumbo, G; Guaragna, A N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of?-Glucosidase Activity for the Treatment of Pompe Disease. J Med Chem60:9462-9469 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sucrase-isomaltase |
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Name: | Sucrase-isomaltase |
Synonyms: | n/a |
Type: | PROTEIN |
Mol. Mass.: | 209081.85 |
Organism: | Mus musculus |
Description: | ChEMBL_701783 |
Residue: | 1818 |
Sequence: | MAKKKFSGLEISLIVLFIIVTIIAIALVVVLATKVPAVEEVKSPTSTPSPGRCPPEQGEP
LNERINCIPEQHPTKAKCEERGCCWRPWNNTIIPWCFFADNHGYTAASVTNDNSGLKATL
SRIPSPTLFGEDIKSVLLTTQSQTRNRFRFKLTDPNNKRYEVPHQFVKDGNGIPAADTLY
DVKVSENPFSIKVIRKSNNKVLFDTSIGPLVYSNQYLQISTRLPSEYIYGFGEHIHKRFR
HDLYWKTWPIFTRDEIPGDNNHNLYGHQTFFMGIEDNSGKSYGVFLMNSNAMEVFIQPTP
IITYRVTGGVLDFYIFLGDTPEQVVQQYQELIGRPAMPAYWNLGFQLSRWNYVSLDKVKE
VVRRNREAGIPYDAQVTDIDYMEDKKDFTYDEVAFKGLPEFAQDLHNHGQKYIIILDPAI
SINKRANGAEYQTYVRGNEQNVWVKESDGTTSLIGEVWPGLTVYPDFTNPRTWEWWANEC
NLFHQQVEYDGLWIDMNEVSSFIHGSQKGCAPNLLNYPPFTPGILDKIMYSKTLCMDAVQ
HWGNQYDVHSLYGYSMAIATEKAVEKVFPNKRSFILTRSTFAGSGHHAAHWLGDNTASWE
QMEWSITGMLEFGMFGMPLVGADICGFLANTTEELCRRWMQLGAFYPFSRNHNAEGYAEQ
DPAFWGADSLLVNTSRHYLTIRYTLLPFLYTLFYRAHAFGETVARPFLHEFYEDPNSWIE
DTQFLWGPALLITPVLRPETKYVSAYIPDATWYDYETGEKRPWRKQRVDMYLPEDKIGLH
LRGGYIIPTQQPDVTTTASRKNPLGLIVALDENQAAKGELFWDDGESKDTIEKKIYILYE
FSVSNNNLIVNCTHSSYPEGNTLVFKTIKVLGLSATVTAVTVGENDQQMNPHLAFTFDAF
NKILSITDLTFNLGKTFIVRWTTQSFSDNEKFTCYPDVGTATEKTCVERGCIWEPVSGLA
NVPPCYFPSNHNPYLLTSTQKLATGITAELQLNPASARIKLPSNPISTLRVEVKYHKNDM
LQFKIYDAHHKRYEVPVPLNIPDTPTSSEENRLYDVEIKENPFGIQVRRRSTGKLIWDSC
LPGFAFNDQFIQISTRLPSQYLYGFGEAEHTAFKRNLNWHTWGMFTRDQPPGYKLNSYGF
HPYYMALEDEGNAHGVLLQNSNGMDVTFQPTPALTYRTIGGILDFYMFLGPTPEGATKQY
HEVIGFPVMPPYWALGFQLCRYGYRNTSEIEQLYNDMKAAQIPYDVQYTDINYMERQLDF
TIGERFKTLPQFVEKIRKEGMKYIVILDPAISGNETQPYPAFERGIQKDVFVKWPNTNDI
CWAKVWPDLPNITIDETITEDEAVNASRAHVAFPDFFRNSTSEWWTREIYDFYNEKMKFD
GLWIDMNEPSSFVNGTVTNKCRNDTLNYPPYFPELTKRNEGLHFRTMCMETEHILSDGSS
VLHYDVHNLYGWSQVKPTLDALRNTTGLRGIVISRSTYPTAGRWGGHWLGDNYANWENLE
KSLIGMLEFNLFGIPYVGADICGFFNDSEYHLCARWMQVGAFYPYSRNHNIQFTRRQDPV
SWNETFAQMSKKVLEIRYTLLPYFYTQMHEAHIHGGTVIRPLMHEFFDDKETWEIYKQFL
WGPAFMVTPVIGPFQTAVNGYVPKARWFDYHTGEDIKVRGKLQTFSAPFDTINLHVRGGY
ILPCQEPAQNTYYSRQNYMKLIVAADDNQTAKGSLFWDDGESIDTYEKNQYTLIEFNLNQ
KTLTSTVLKNGYRNKSEMKLGNIYVWGKGTTHINQVNLTYGGNEQQLLFTQDEAKEILTI
ELKNVNVTLDEPIQISWS
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BDBM18355 |
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n/a |
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Name | BDBM18355 |
Synonyms: | (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL1029 | MIGLUSTAT | N-Butyl-DNJ | US20230339856, Compound NB-DNJ | US9181184, 5 |
Type | Small organic molecule |
Emp. Form. | C10H21NO4 |
Mol. Mass. | 219.278 |
SMILES | CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
Structure |
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