Reaction Details |
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Target | Serine/threonine-protein kinase TNNI3K |
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Ligand | BDBM50197736 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1674597 (CHEMBL4024626) |
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IC50 | 2500±n/a nM |
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Citation | Philp, J; Lawhorn, BG; Graves, AP; Shewchuk, L; Rivera, KL; Jolivette, LJ; Holt, DA; Gatto, GJ; Kallander, LS 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem61:3076-3088 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase TNNI3K |
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Name: | Serine/threonine-protein kinase TNNI3K |
Synonyms: | CARK | Serine/threonine-protein kinase TNNI3K | TNI3K_HUMAN | TNNI3K |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 92855.14 |
Organism: | Homo sapiens (Human) |
Description: | gi_7705748 |
Residue: | 835 |
Sequence: | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
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BDBM50197736 |
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n/a |
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Name | BDBM50197736 |
Synonyms: | CHEMBL3981783 |
Type | Small organic molecule |
Emp. Form. | C18H19ClN6O2S |
Mol. Mass. | 418.9 |
SMILES | CNc1ccc(cc1Nc1cc(Nc2ccc(Cl)cc2)ncn1)S(=O)(=O)NC |
Structure |
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