| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TNNI3K |
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| Ligand | BDBM50245273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1674597 (CHEMBL4024626) |
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| IC50 | 200±n/a nM |
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| Citation |  Philp, J; Lawhorn, BG; Graves, AP; Shewchuk, L; Rivera, KL; Jolivette, LJ; Holt, DA; Gatto, GJ; Kallander, LS 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem61:3076-3088 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TNNI3K |
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| Name: | Serine/threonine-protein kinase TNNI3K |
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| Synonyms: | CARK | Serine/threonine-protein kinase TNNI3K | TNI3K_HUMAN | TNNI3K |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 92855.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_7705748 |
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| Residue: | 835 |
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| Sequence: | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
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| BDBM50245273 |
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| n/a |
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| Name | BDBM50245273 |
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| Synonyms: | CHEMBL4100539 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N5O4S2 |
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| Mol. Mass. | 433.505 |
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| SMILES | CNS(=O)(=O)c1cccc(Nc2cc(Nc3cccc(c3)S(C)(=O)=O)ncn2)c1 |
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| Structure | 
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