| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 2 |
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| Ligand | BDBM50245388 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1674663 (CHEMBL4024806) |
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| IC50 | 123±n/a nM |
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| Citation |  Kokkala, P; Mpakali, A; Mauvais, FX; Papakyriakou, A; Daskalaki, I; Petropoulou, I; Kavvalou, S; Papathanasopoulou, M; Agrotis, S; Fonsou, TM; van Endert, P; Stratikos, E; Georgiadis, D Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides. J Med Chem59:9107-9123 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum aminopeptidase 2 |
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| Name: | Endoplasmic reticulum aminopeptidase 2 |
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| Synonyms: | Aminopeptidase | ERAP2 | ERAP2_HUMAN | LRAP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 110463.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473169 |
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| Residue: | 960 |
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| Sequence: | MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGE
RFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNA
TLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY
KSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVK
TIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYAL
QASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASD
KLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNV
CFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQ
YLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTT
WTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVI
HRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRV
GLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISE
NLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMES
SGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKL
IELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISG
TTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT
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| BDBM50245388 |
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| n/a |
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| Name | BDBM50245388 |
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| Synonyms: | CHEMBL4081073 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34ClN4O5P |
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| Mol. Mass. | 609.052 |
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| SMILES | N[C@@H](CCc1ccccc1)P(O)(=O)C[C@@H](Cc1cc(no1)-c1ccccc1Cl)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| |
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| Structure | 
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