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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor | ||
| Ligand | BDBM50245706 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1675765 (CHEMBL4025908) | ||
| IC50 | 34320±n/a nM | ||
| Citation |  Patel, HM; Pawara, R; Ansari, A; Noolvi, M; Surana, S Design and synthesis of quinazolinones as EGFR inhibitors to overcome EGFR resistance obstacle. Bioorg Med Chem25:2713-2723 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor | |||
| Name: | Epidermal growth factor receptor | ||
| Synonyms: | EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1 | ||
| Type: | Receptor Kinase Domain | ||
| Mol. Mass.: | 134279.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533 | ||
| Residue: | 1210 | ||
| Sequence: |
| ||
| BDBM50245706 | |||
| n/a | |||
| Name | BDBM50245706 | ||
| Synonyms: | CHEMBL4072392 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H15ClN2O2 | ||
| Mol. Mass. | 374.82 | ||
| SMILES | CC(=O)c1ccccc1-n1c(nc2cc(Cl)ccc2c1=O)-c1ccccc1 |(31.48,-28.12,;30.56,-29.35,;29.03,-29.16,;31.17,-30.79,;32.48,-30.02,;33.82,-30.78,;33.83,-32.31,;32.51,-33.08,;31.18,-32.31,;29.86,-33.08,;29.87,-34.64,;28.52,-35.42,;27.18,-34.65,;25.84,-35.42,;24.5,-34.65,;23.17,-35.42,;24.5,-33.1,;25.83,-32.33,;27.17,-33.09,;28.51,-32.31,;28.5,-30.76,;31.2,-35.41,;31.2,-36.95,;32.54,-37.72,;33.87,-36.94,;33.86,-35.39,;32.53,-34.63,)| | ||
| Structure | 
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