| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM31768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48190 (CHEMBL665986) |
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| IC50 | 152±n/a nM |
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| Citation |  Rotstein, DM; Kertesz, DJ; Walker, KA; Swinney, DC Stereoisomers of ketoconazole: preparation and biological activity. J Med Chem35:2818-25 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_BOVIN | CYP11B1 | Cytochrome P450 11B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57863.81 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1345884 |
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| Residue: | 503 |
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| Sequence: | MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKEQS
SENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLAYR
QARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNA
RGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLMFV
PRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMT
LDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRAIT
ELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARP
ESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQED
IKMVYRFILMPSTLPLFTFRAIQ
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| BDBM31768 |
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| n/a |
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| Name | BDBM31768 |
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| Synonyms: | CHEMBL295698 | Ketoconazole | Nizoral | Panfungol |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28Cl2N4O4 |
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| Mol. Mass. | 531.431 |
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| SMILES | CC(=O)N1CCN(CC1)c1ccc(OC[C@@H]2CO[C@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 |r| |
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| Structure | 
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