| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
|---|
| Ligand | BDBM50247168 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1677666 (CHEMBL4027809) |
|---|
| IC50 | 1.8±n/a nM |
|---|
| Citation |  Li, B; Ni, S; Mao, F; Chen, F; Liu, Y; Wei, H; Chen, W; Zhu, J; Lan, L; Li, J Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. J Med Chem61:224-250 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
|---|
| Name: | 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
|---|
| Synonyms: | 4,4'-diapophytoene desaturase | CRTN_STAAE | Dehydrosqualene desaturase | Diapophytoene desaturase | crtN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56731.85 |
|---|
| Organism: | Staphylococcus aureus (strain Newman) |
|---|
| Description: | ChEMBL_116799 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MKIAVIGAGVTGLAAAARIASQGHEVTIFEKNNNVGGRMNQLKKDGFTFDMGPTIVMMPD
VYKDVFTACGKNYEDYIELRQLRYIYDVYFDHDDRITVPTDLAELQQMLESIEPGSTHGF
MSFLTDVYKKYEIARRYFLERTYRKPSDFYNMTSLVQGAKLKTLNHADQLIEHYIDNEKI
QKLLAFQTLYIGIDPKRGPSLYSIIPMIEMMFGVHFIKGGMYGMAQGLAQLNKDLGVNIE
LNAEIEQIIIDPKFKRADAIKVNGDIRKFDKILCTADFPSVAESLMPDFAPIKKYPPHKI
ADLDYSCSAFLMYIGIDIDVTDQVRLHNVIFSDDFRGNIEEIFEGRLSYDPSIYVYVPAV
ADKSLAPEGKTGIYVLMPTPELKTGSGIDWSDEALTQQIKEIIYRKLATIEVFEDIKSHI
VSETIFTPNDFEQTYHAKFGSAFGLMPTLAQSNYYRPQNVSRDYKDLYFAGASTHPGAGV
PIVLTSAKITVDEMIKDIERGV
|
|
|
|---|
| BDBM50247168 |
|---|
| n/a |
|---|
| Name | BDBM50247168 |
|---|
| Synonyms: | CHEMBL4086008 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24ClNO |
|---|
| Mol. Mass. | 389.917 |
|---|
| SMILES | Cl.CN(C\C=C\c1ccc(cc1)-c1ccccc1)Cc1coc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
