| Reaction Details |
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 | Report a problem with these data |
| Target | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
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| Ligand | BDBM261603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1678430 (CHEMBL4028573) |
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| IC50 | 1055±n/a nM |
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| Citation |  Pellicciari, R; Liscio, P; Giacchè, N; De Franco, F; Carotti, A; Robertson, J; Cialabrini, L; Katsyuba, E; Raffaelli, N; Auwerx, J ?-Amino-?-carboxymuconate-?-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD J Med Chem61:745-759 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
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| Name: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
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| Synonyms: | ACMSD | ACMSD_HUMAN | Picolinate carboxylase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38037.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDX5 |
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| Residue: | 336 |
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| Sequence: | MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRI
REMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQ
APELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQM
DGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGF
SMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELE
PGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
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| BDBM261603 |
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| n/a |
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| Name | BDBM261603 |
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| Synonyms: | US10513499, Compound 14 | US11254644, Compound 14 | US9708272, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O3S |
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| Mol. Mass. | 338.38 |
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| SMILES | OC(=O)c1cccc(CSc2nc(cc(=O)[nH]2)-c2ccccc2)c1 |
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| Structure | 
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