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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile salt export pump | ||
| Ligand | BDBM50035696 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1678644 (CHEMBL4028921) | ||
| IC50 | >133000±n/a nM | ||
| Citation |  Morgan, RE; van Staden, CJ; Chen, Y; Kalyanaraman, N; Kalanzi, J; Dunn, RT; Afshari, CA; Hamadeh, HK A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci136:216-41 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile salt export pump | |||
| Name: | Bile salt export pump | ||
| Synonyms: | ABCB11 | ABCBB_HUMAN | ATP-binding cassette sub-family B member 11 | BSEP | Bile Salt Export Pump, BSEP | Bile salt export pump | Bile salt export pump (BSEP) | ||
| Type: | Protein | ||
| Mol. Mass.: | 146405.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O95342 | ||
| Residue: | 1321 | ||
| Sequence: |
| ||
| BDBM50035696 | |||
| n/a | |||
| Name | BDBM50035696 | ||
| Synonyms: | 1,1''-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane} | 1,4,8,11-tetraazacyclotetradecanyl[4-(1,4,8,11-tetraazacyclotetradecanylmethyl)phenyl]methane | 1,4,8,11-tetraazacyclotetradecanyl[4-(1,4,8,11-tetraazacyclotetradecanylmethyl)phenyl]methane(8HBr.2H2O) | 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene | 11''-xylyl bis-1,4,8,11-tetraazacyclotetradecane | 11-{4-[4,8, 11-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester | AMD-3100 | CHEMBL18442 | CHEMBL2311089 | PLERIXAFOR | PLERIXAFOR OCTAHYDROCHLORIDE | US9205085, MSX-162 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H54N8 | ||
| Mol. Mass. | 502.782 | ||
| SMILES | C(N1CCCNCCNCCCNCC1)c1ccc(CN2CCCNCCNCCCNCC2)cc1 | ||
| Structure | 
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