| Reaction Details |
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 | Report a problem with these data |
| Target | Homeobox protein Nkx-2.5/Transcription factor GATA-4 |
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| Ligand | BDBM50249847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1680721 (CHEMBL4030998) |
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| IC50 | 9000±n/a nM |
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| Citation |  Välimäki, MJ; Tölli, MA; Kinnunen, SM; Aro, J; Serpi, R; Pohjolainen, L; Talman, V; Poso, A; Ruskoaho, HJ Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. J Med Chem60:7781-7798 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeobox protein Nkx-2.5/Transcription factor GATA-4 |
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| Name: | Homeobox protein Nkx-2.5/Transcription factor GATA-4 |
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| Synonyms: | GATA4/NKX2-5 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1680721 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Transcription factor GATA-4 |
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| Synonyms: | GATA-binding factor 4 | GATA4_MOUSE | Gata-4 | Gata4 | Transcription factor GATA-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44598.13 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117707 |
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| Residue: | 441 |
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| Sequence: | MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSA
AAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAA
AAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAAS
AGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNAC
GLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKL
HGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSE
EMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQAS
SKQDSWNSLVLADSHGDIITA
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| Component 2 |
| Name: | Homeobox protein Nkx-2.5 |
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| Synonyms: | Cardiac-specific homeobox | Csx | Homeobox protein CSX | Homeobox protein NK-2 homolog E | Homeobox protein Nkx-2.5 | NKX25_MOUSE | Nkx-2.5 | Nkx2-5 | Nkx2e |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34174.01 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117707 |
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| Residue: | 318 |
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| Sequence: | MFPSPALTPTPFSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEA
AASGLAELRAEMGPAPSPPKCSPAFPAAPTFYPGAYGDPDPAKDPRADKKELCALQKAVE
LDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQ
VKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDPAAYAPAYGVG
LNAYGYNAYPYPSYGGAACSPGYSCAAYPAAPPAAQPPAASANSNFVNFGVGDLNTVQSP
GMPQGNSGVSTLHGIRAW
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| BDBM50249847 |
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| n/a |
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| Name | BDBM50249847 |
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| Synonyms: | CHEMBL4095473 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17NO3S |
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| Mol. Mass. | 303.376 |
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| SMILES | CC(C)COC(=O)c1ccc(NC(=O)c2cccs2)cc1 |
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| Structure | 
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