Reaction Details |
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Target | Acid-sensing ion channel 1 |
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Ligand | BDBM50009859 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1680967 |
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IC50 | 134896±n/a nM |
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Citation | Lynagh, T; Romero-Rojo, JL; Lund, C; Pless, SA Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen. J Med Chem60:8192-8200 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acid-sensing ion channel 1 |
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Name: | Acid-sensing ion channel 1 |
Synonyms: | ASIC1_RAT | Accn2 | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | Asic1 | Bnac2 | Brain sodium channel 2 |
Type: | PROTEIN |
Mol. Mass.: | 59630.33 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_109766 |
Residue: | 526 |
Sequence: | MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
CTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACS
AEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFF
DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV
CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ
KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRSSADK
GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
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BDBM50009859 |
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n/a |
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Name | BDBM50009859 |
Synonyms: | (+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid | (+-)-ibuprofen | (+-)-p-isobutylhydratropic acid | (4-isobutylphenyl)-alpha-methylacetic acid | (RS)-ibuprofen | 2-(4-isobutylphenyl)propanoic acid | 2-[4-(2-methylpropyl)phenyl]propanoic acid | 4-isobutylhydratropic acid | Advil | Brufen | CHEMBL521 | IBUPROFEN LYSINE | Ibuprofen | Ibuprofen (1) | Motrin | alpha-(4-isobutylphenyl)propionic acid | alpha-(p-isobutylphenyl)propionic acid |
Type | Small organic molecule |
Emp. Form. | C13H18O2 |
Mol. Mass. | 206.2808 |
SMILES | CC(C)Cc1ccc(cc1)C(C)C(O)=O |
Structure |
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