| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Ligand | BDBM50250272 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1681419 |
|---|
| IC50 | >500000±n/a nM |
|---|
| Citation |  Jørgensen, L; Al-Khawaja, A; Kickinger, S; Vogensen, SB; Skovgaard-Petersen, J; Rosenthal, E; Borkar, N; Löffler, R; Madsen, KK; Bräuner-Osborne, H; Schousboe, A; Ecker, GF; Wellendorph, P; Clausen, RP Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem60:8834-8846 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Synonyms: | GABA transporter 1 | GABATR | GABT1 | GAT-1 | GAT1 | SC6A1_HUMAN | SLC6A1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67079.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1454196 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
|
|
|
|---|
| BDBM50250272 |
|---|
| n/a |
|---|
| Name | BDBM50250272 |
|---|
| Synonyms: | CHEMBL4078727 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21F3N2O |
|---|
| Mol. Mass. | 362.3887 |
|---|
| SMILES | FC(F)(F)c1cccc(c1)C(=O)NC1CCN(Cc2ccccc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
