| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
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| Ligand | BDBM50250267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1681420 (CHEMBL4031697) |
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| IC50 | 18000±n/a nM |
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| Citation |  Jørgensen, L; Al-Khawaja, A; Kickinger, S; Vogensen, SB; Skovgaard-Petersen, J; Rosenthal, E; Borkar, N; Löffler, R; Madsen, KK; Bräuner-Osborne, H; Schousboe, A; Ecker, GF; Wellendorph, P; Clausen, RP Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem60:8834-8846 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent betaine transporter |
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| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | Betaine transporter | S6A12_HUMAN | SLC6A12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69366.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454199 |
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| Residue: | 614 |
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| Sequence: | MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
TREGLIAGEKETHL
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| BDBM50250267 |
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| n/a |
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| Name | BDBM50250267 |
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| Synonyms: | CHEMBL1882801 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20Cl2N2O |
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| Mol. Mass. | 363.281 |
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| SMILES | Clc1ccc(C(=O)NC2CCN(Cc3ccccc3)CC2)c(Cl)c1 |
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| Structure | 
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