| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Ligand | BDBM50250284 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1681422 |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Jørgensen, L; Al-Khawaja, A; Kickinger, S; Vogensen, SB; Skovgaard-Petersen, J; Rosenthal, E; Borkar, N; Löffler, R; Madsen, KK; Bräuner-Osborne, H; Schousboe, A; Ecker, GF; Wellendorph, P; Clausen, RP Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem60:8834-8846 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 3 |
|---|
| Synonyms: | GABA transporter 3 | GABT3 | GAT-3 | GAT3 | S6A11_HUMAN | SLC6A11 | Solute carrier family 6 member 11 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 70607.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1454198 |
|---|
| Residue: | 632 |
|---|
| Sequence: | MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
|
|
|
|---|
| BDBM50250284 |
|---|
| n/a |
|---|
| Name | BDBM50250284 |
|---|
| Synonyms: | CHEMBL4102978 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19Cl2N3O3 |
|---|
| Mol. Mass. | 408.278 |
|---|
| SMILES | [O-][N+](=O)c1ccccc1CN1CCC(CC1)NC(=O)c1ccc(Cl)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
