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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Ligand | BDBM50251669 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1684253 (CHEMBL4034732) | ||
| Ki | 262±n/a nM | ||
| Citation |  Zhao, B; Sensintaffar, J; Bian, Z; Belmar, J; Lee, T; Olejniczak, ET; Fesik, SW Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin. Bioorg Med Chem25:3087-3092 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | |||
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 | ||
| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT | ||
| Type: | Membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 37332.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07820 | ||
| Residue: | 350 | ||
| Sequence: |
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| BDBM50251669 | |||
| n/a | |||
| Name | BDBM50251669 | ||
| Synonyms: | CHEMBL4073037 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H28ClN3O3 | ||
| Mol. Mass. | 465.972 | ||
| SMILES | Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(O)=O |(25.12,-5.86,;26.58,-5.38,;27.05,-3.91,;28.59,-3.91,;29.49,-2.66,;29.07,-5.37,;30.54,-5.84,;27.83,-6.28,;27.84,-7.82,;26.51,-8.59,;26.51,-10.13,;27.84,-10.9,;29.18,-10.12,;30.65,-10.59,;31.14,-12.05,;30.12,-13.2,;30.6,-14.66,;29.58,-15.81,;30.06,-17.28,;29.03,-18.42,;29.52,-19.88,;28.49,-21.03,;31.03,-20.2,;31.51,-21.66,;32.05,-19.04,;33.56,-19.34,;31.56,-17.58,;31.55,-9.34,;30.64,-8.09,;29.18,-8.58,;33.09,-9.33,;33.86,-7.99,;33.87,-10.66,)| | ||
| Structure | 
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