| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
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| Ligand | BDBM50252231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684486 |
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| IC50 | 5.5±n/a nM |
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| Citation |  Galal, SA; Abdelsamie, AS; Shouman, SA; Attia, YM; Ali, HI; Tabll, A; El-Shenawy, R; El Abd, YS; Ali, MM; Mahmoud, AE; Abdel-Halim, AH; Fyiad, AA; Girgis, AS; El-Diwani, HI Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs. Eur J Med Chem134:392-405 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk2 |
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| Name: | Serine/threonine-protein kinase Chk2 |
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| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
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| Type: | Protein |
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| Mol. Mass.: | 60908.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96017 |
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| Residue: | 543 |
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| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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| BDBM50252231 |
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| n/a |
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| Name | BDBM50252231 |
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| Synonyms: | CHEMBL4072515 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H24N6O4 |
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| Mol. Mass. | 544.5601 |
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| SMILES | Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(=O)NCc2ccccc2)c1[N+]([O-])=O)-c1ccccc1 |
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| Structure | 
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