| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50252265 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1684531 |
|---|
| IC50 | >200000±n/a nM |
|---|
| Citation |  Knutsson, S; Kindahl, T; Engdahl, C; Nikjoo, D; Forsgren, N; Kitur, S; Ekström, F; Kamau, L; Linusson, A N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes. Eur J Med Chem134:415-427 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACE1 | ACE1 | ACES_ANOGA | ACHE1 | AChE | Ace | Acetylcholinesterase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 80902.47 |
|---|
| Organism: | Anopheles gambiae |
|---|
| Description: | ChEMBL_104567 |
|---|
| Residue: | 737 |
|---|
| Sequence: | MEIRGLLMGRLRLGRRMVPLGLLGVTALLLILPPFALVQGRHHELNNGAAIGSHQLSAAA
GVGLASQSAQSGSLASGVMSSVPAAGASSSSSSSLLSSSAEDDVARITLSKDADAFFTPY
IGHGESVRIIDAELGTLEHVHSGATPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGITV
DAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTTPPNSCVQIVDTVFGDFP
GATMWNPNTPLSEDCLYINVVAPRPRPKNAAVMLWIFGGGFYSGTATLDVYDHRALASEE
NVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGES
AGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSK
LSDAVECLRGKDPHVLVNNEWGTLGICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT
GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE
PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH
GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH
GRHYLELGLNTSFVGRGPRLRQCAFWKKYLPQLVAATSNLPGPAPPSEPCESSAFFYRPD
LIVLLVSLLTATVRFIQ
|
|
|
|---|
| BDBM50252265 |
|---|
| n/a |
|---|
| Name | BDBM50252265 |
|---|
| Synonyms: | CHEMBL1311140 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H21N3O2S |
|---|
| Mol. Mass. | 295.4 |
|---|
| SMILES | COc1ccccc1N=C(S)NCCN1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
