| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50252272 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684531 |
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| IC50 | 7800±n/a nM |
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| Citation |  Knutsson, S; Kindahl, T; Engdahl, C; Nikjoo, D; Forsgren, N; Kitur, S; Ekström, F; Kamau, L; Linusson, A N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes. Eur J Med Chem134:415-427 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACE1 | ACE1 | ACES_ANOGA | ACHE1 | AChE | Ace | Acetylcholinesterase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80902.47 |
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| Organism: | Anopheles gambiae |
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| Description: | ChEMBL_104567 |
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| Residue: | 737 |
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| Sequence: | MEIRGLLMGRLRLGRRMVPLGLLGVTALLLILPPFALVQGRHHELNNGAAIGSHQLSAAA
GVGLASQSAQSGSLASGVMSSVPAAGASSSSSSSLLSSSAEDDVARITLSKDADAFFTPY
IGHGESVRIIDAELGTLEHVHSGATPRRRGLTRRESNSDANDNDPLVVNTDKGRIRGITV
DAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTTPPNSCVQIVDTVFGDFP
GATMWNPNTPLSEDCLYINVVAPRPRPKNAAVMLWIFGGGFYSGTATLDVYDHRALASEE
NVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGES
AGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSK
LSDAVECLRGKDPHVLVNNEWGTLGICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT
GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE
PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH
GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH
GRHYLELGLNTSFVGRGPRLRQCAFWKKYLPQLVAATSNLPGPAPPSEPCESSAFFYRPD
LIVLLVSLLTATVRFIQ
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| BDBM50252272 |
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| n/a |
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| Name | BDBM50252272 |
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| Synonyms: | CHEMBL4079963 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H22N4O2S2 |
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| Mol. Mass. | 342.48 |
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| SMILES | NS(=O)(=O)c1ccc(NC(=S)NCCN2CCCCC2)cc1 |
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| Structure | 
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