| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50252441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684933 |
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| EC50 | >10.0±n/a nM |
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| Citation |  Thum, S; Kokornaczyk, AK; Seki, T; De Maria, M; Ortiz Zacarias, NV; de Vries, H; Weiss, C; Koch, M; Schepmann, D; Kitamura, M; Tschammer, N; Heitman, LH; Junker, A; Wünsch, B Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold. Eur J Med Chem135:401-413 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50252441 |
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| n/a |
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| Name | BDBM50252441 |
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| Synonyms: | CHEMBL4061166 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N4O4 |
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| Mol. Mass. | 518.6471 |
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| SMILES | CC(C)CN1CC(=Cc2ccc(NC(C)=O)cc2C1=O)C(=O)Nc1ccc(CN(C)C2CCOCC2)cc1 |c:6| |
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| Structure | 
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