| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic endo-beta-N-acetylglucosaminidase |
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| Ligand | BDBM50402289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1685304 |
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| IC50 | 20000±n/a nM |
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| Citation |  Bi, Y; Might, M; Vankayalapati, H; Kuberan, B Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-?-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett27:2962-2966 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic endo-beta-N-acetylglucosaminidase |
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| Name: | Cytosolic endo-beta-N-acetylglucosaminidase |
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| Synonyms: | ENASE_HUMAN | ENGASE | Endo-beta-N-acetylglucosaminidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83989.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_467019 |
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| Residue: | 743 |
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| Sequence: | MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFR
EVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSS
QRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTA
HRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSL
SLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGF
FTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVAL
FAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEA
VGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAV
RLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLR
PLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCR
LGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRC
FRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPV
PKEGFRVPQAEWGRAVLLYSAPA
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| BDBM50402289 |
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| n/a |
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| Name | BDBM50402289 |
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| Synonyms: | TENATOPRAZOLE |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N4O3S |
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| Mol. Mass. | 346.404 |
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| SMILES | COc1ccc2[nH]c(nc2n1)S(=O)Cc1ncc(C)c(OC)c1C |
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| Structure | 
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