Reaction Details |
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Target | Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
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Ligand | BDBM50007129 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_34221 (CHEMBL648715) |
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Ki | 40±n/a nM |
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Citation | DeNinno, MP; Schoenleber, R; Perner, RJ; Lijewski, L; Asin, KE; Britton, DR; MacKenzie, R; Kebabian, JW Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. J Med Chem34:2561-9 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
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Name: | Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor |
Synonyms: | Adrenergic receptor alpha-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 935397 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Alpha-2C adrenergic receptor |
Synonyms: | ADA2C_RAT | Adra2c | Adrenergic receptor alpha | Alpha-2C adrenergic receptor | adrenergic Alpha2 | adrenergic Alpha2C |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49890.50 |
Organism: | RAT |
Description: | adrenergic Alpha2 0 RAT::P22086 |
Residue: | 458 |
Sequence: | MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRR
GGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRAR
SSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFW
IGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
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Component 2 |
Name: | Alpha-2B adrenergic receptor |
Synonyms: | ADA2B_RAT | Adra2b | Adrenergic receptor alpha | Adrenergic receptor alpha-2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | adrenergic Alpha2B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50379.83 |
Organism: | NEONATAL RAT |
Description: | adrenergic Alpha2B ADRA2B NEONATAL RAT::P19328 |
Residue: | 453 |
Sequence: | MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLA
AADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS
RALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILA
SSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVP
TLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAE
EGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWW
RRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYC
NSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
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Component 3 |
Name: | Alpha-2A adrenergic receptor [16-465] |
Synonyms: | ADA2A_RAT | Adra2a | Adrenaline 2 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha2 Adrenoreceptor | CA2-47 | adrenergic Alpha2A |
Type: | G-protein coupled receptor |
Mol. Mass.: | 48961.69 |
Organism: | Rattus norvegicus (rat) |
Description: | P22909[16-465] |
Residue: | 450 |
Sequence: | MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGG
QQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACS
APPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSE
HAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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BDBM50007129 |
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n/a |
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Name | BDBM50007129 |
Synonyms: | (1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol | 1-Aminomethyl-3-phenyl-isochroman-5,6-diol | A-70108 | CHEMBL86931 |
Type | Small organic molecule |
Emp. Form. | C16H17NO3 |
Mol. Mass. | 271.3111 |
SMILES | NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c1ccccc1 |
Structure |
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