| Reaction Details |
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 | Report a problem with these data |
| Target | S-adenosylmethionine decarboxylase proenzyme |
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| Ligand | BDBM50254820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1686749 |
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| IC50 | >180000±n/a nM |
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| Citation |  Volkov, OA; Brockway, AJ; Wring, SA; Peel, M; Chen, Z; Phillips, MA; De Brabander, JK Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. J Med Chem61:1182-1203 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-adenosylmethionine decarboxylase proenzyme |
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| Name: | S-adenosylmethionine decarboxylase proenzyme |
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| Synonyms: | AMD | AMD1 | DCAM_HUMAN | S-Adenosylmethionine Decarboxylase (AdoMetDC) | S-adenosylmethionine decarboxylase 1 | SAMDC |
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| Type: | Heterotetramer of two alpha and two beta chains |
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| Mol. Mass.: | 38337.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | For the production of protein for the hAdoMetDC enzyme assays, the plasmid containing (H)6 tag at the carboxyl end (replacing -QQQQQS) was used. |
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| Residue: | 334 |
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| Sequence: | MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQ
EAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKP
SHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEIL
MSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYW
TIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQ
KIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
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| BDBM50254820 |
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| n/a |
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| Name | BDBM50254820 |
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| Synonyms: | CHEMBL4099923 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15Cl2N5 |
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| Mol. Mass. | 312.198 |
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| SMILES | CN(C)c1c(Cl)cc(Nc2cc(C)nc(N)n2)cc1Cl |
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| Structure | 
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