| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasma kallikrein |
|---|
| Ligand | BDBM50256261 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1687648 |
|---|
| Ki | 54±n/a nM |
|---|
| Citation |  Teufel, DP; Bennett, G; Harrison, H; van Rietschoten, K; Pavan, S; Stace, C; Le Floch, F; Van Bergen, T; Vermassen, E; Barbeaux, P; Hu, TT; Feyen, JHM; Vanhove, M Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema. J Med Chem61:2823-2836 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasma kallikrein |
|---|
| Name: | Plasma kallikrein |
|---|
| Synonyms: | 3.4.21.34 | Fletcher factor | KLKB1_MOUSE | Kininogenin | Klk3 | Klkb1 | Pk | Plasma kallikrein | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 71398.99 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_103492 |
|---|
| Residue: | 638 |
|---|
| Sequence: | MILFNRVGYFVSLFATVSCGCMTQLYKNTFFRGGDLAAIYTPDAQYCQKMCTFHPRCLLF
SFLAVTPPKETNKRFGCFMKESITGTLPRIHRTGAISGHSLKQCGHQISACHRDIYKGLD
MRGSNFNISKTDNIEECQKLCTNNFHCQFFTYATSAFYRPEYRKKCLLKHSASGTPTSIK
SADNLVSGFSLKSCALSEIGCPMDIFQHSAFADLNVSQVITPDAFVCRTICTFHPNCLFF
TFYTNEWETESQRNVCFLKTSKSGRPSPPIPQENAISGYSLLTCRKTRPEPCHSKIYSGV
DFEGEELNVTFVQGADVCQETCTKTIRCQFFIYSLLPQDCKEEGCKCSLRLSTDGSPTRI
TYGMQGSSGYSLRLCKLVDSPDCTTKINARIVGGTNASLGEWPWQVSLQVKLVSQTHLCG
GSIIGRQWVLTAAHCFDGIPYPDVWRIYGGILSLSEITKETPSSRIKELIIHQEYKVSEG
NYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGETQNILQKATI
PLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGRWQLVGITSWGE
GCARKDQPGVYTKVSEYMDWILEKTQSSDVRALETSSA
|
|
|
|---|
| BDBM50256261 |
|---|
| n/a |
|---|
| Name | BDBM50256261 |
|---|
| Synonyms: | CHEMBL4059991 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C117H160N32O28S3 |
|---|
| Mol. Mass. | 2558.915 |
|---|
| SMILES | CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSCc3cc(CSC[C@@H](NC1=O)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(O)=O)cc(CSC[C@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N2)c3 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
