| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50256677 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1688152 |
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| Ki | 45±n/a nM |
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| Citation |  Truong, PM; Hassan, SA; Lee, YS; Kopajtic, TA; Katz, JL; Chadderdon, AM; Traynor, JR; Deschamps, JR; Jacobson, AE; Rice, KC Modulation of opioid receptor affinity and efficacy via N-substitution of 9?-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study. Bioorg Med Chem25:2406-2422 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50256677 |
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| n/a |
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| Name | BDBM50256677 |
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| Synonyms: | CHEMBL4101657 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H31NO6 |
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| Mol. Mass. | 453.5274 |
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| SMILES | OC(=O)C(O)=O.[H][C@]12CCC[C@](CCN1C[C@@H]1C[C@H]1c1ccccc1)([C@H]2O)c1cccc(O)c1 |r,TLB:15:14:10.9.8:25| |
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| Structure | 
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