Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 2 | ||
| Ligand | BDBM50257509 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1689937 (CHEMBL4040507) | ||
| Kd | 10±n/a nM | ||
| Citation |  Doornbos, MLJ; Cid, JM; Haubrich, J; Nunes, A; van de Sande, JW; Vermond, SC; Mulder-Krieger, T; Trabanco, AA; Ahnaou, A; Drinkenburg, WH; Lavreysen, H; Heitman, LH; IJzerman, AP; Tresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem60:6704-6720 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 2 | |||
| Name: | Metabotropic glutamate receptor 2 | ||
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 95584.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14416 | ||
| Residue: | 872 | ||
| Sequence: |
| ||
| BDBM50257509 | |||
| n/a | |||
| Name | BDBM50257509 | ||
| Synonyms: | CHEMBL4076639 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24ClF3N4O | ||
| Mol. Mass. | 464.911 | ||
| SMILES | O[C@H]1CC[C@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,1.0,(26.17,-42.93,;26.17,-41.39,;24.84,-40.61,;24.85,-39.08,;26.19,-38.32,;27.52,-39.08,;27.51,-40.62,;26.19,-36.78,;27.52,-36.01,;28.85,-36.78,;30.19,-36.01,;30.19,-34.46,;28.85,-33.69,;27.52,-34.46,;26.19,-33.69,;31.51,-33.68,;32.85,-34.45,;34.18,-33.68,;34.18,-32.14,;35.32,-31.1,;36.82,-31.42,;37.31,-32.88,;37,-34.38,;38.46,-33.9,;34.69,-29.7,;33.16,-29.87,;32.84,-31.37,;31.5,-32.14,;30.17,-31.38,;30.16,-29.84,;28.84,-32.15,;28.82,-30.61,)| | ||
| Structure | 
| ||