| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM50257938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1690072 |
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| EC50 | 3790±n/a nM |
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| Citation |  Marinozzi, M; Castro Navas, FF; Maggioni, D; Carosati, E; Bocci, G; Carloncelli, M; Giorgi, G; Cruciani, G; Fontana, R; Russo, V Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. J Med Chem60:6548-6562 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50257938 |
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| n/a |
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| Name | BDBM50257938 |
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| Synonyms: | CHEMBL4089508 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H48O2 |
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| Mol. Mass. | 428.6902 |
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| SMILES | [H][C@@]1(O[C@]1([H])[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@H](CC)C(C)C |r,t:17| |
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| Structure | 
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