| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50258943 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1690819 (CHEMBL4041389) |
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| Ki | 54±n/a nM |
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| Citation |  Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor. J Med Chem60:8103-8114 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R_MOUSE | Mc4r |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36964.43 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1498850 |
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| Residue: | 332 |
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| Sequence: | MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVS
GVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTN
MKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPL
IYALRSQELRKTFKEIICFYPLGGICELSSRY
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| BDBM50258943 |
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| n/a |
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| Name | BDBM50258943 |
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| Synonyms: | CHEMBL4060087 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H53N11O9S2 |
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| Mol. Mass. | 872.026 |
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| SMILES | C[C@@H]1NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC1=O |r| |
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| Structure | 
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