| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Ligand | BDBM50259357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1691315 |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. Eur J Med Chem125:696-709 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|
| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 69222.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y463 |
|---|
| Residue: | 629 |
|---|
| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
|
|
|
|---|
| BDBM50259357 |
|---|
| n/a |
|---|
| Name | BDBM50259357 |
|---|
| Synonyms: | CHEMBL4091942 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H9ClN4 |
|---|
| Mol. Mass. | 268.701 |
|---|
| SMILES | Clc1ccc2ncc(-c3ccc4[nH]ccc4c3)n2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
