| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Ligand | BDBM50259518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1691316 |
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| IC50 | 1400±n/a nM |
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| Citation |  Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. Eur J Med Chem125:696-709 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Synonyms: | DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66690.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508025 |
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| Residue: | 601 |
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| Sequence: | MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
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| BDBM50259518 |
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| n/a |
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| Name | BDBM50259518 |
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| Synonyms: | CHEMBL4077125 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H10N6O |
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| Mol. Mass. | 242.2367 |
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| SMILES | COc1ccc2ncc(-c3ccnc(N)n3)n2n1 |
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| Structure | 
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