| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Ligand | BDBM50259467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1691317 |
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| IC50 | 2100±n/a nM |
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| Citation |  Bendjeddou, LZ; Loaëc, N; Villiers, B; Prina, E; Späth, GF; Galons, H; Meijer, L; Oumata, N Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. Eur J Med Chem125:696-709 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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| Synonyms: | DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65747.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508026 |
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| Residue: | 588 |
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| Sequence: | MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
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| BDBM50259467 |
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| n/a |
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| Name | BDBM50259467 |
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| Synonyms: | CHEMBL4070189 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N4O3S |
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| Mol. Mass. | 360.431 |
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| SMILES | CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(c3)S(C)(=O)=O)n2n1 |r| |
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| Structure | 
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