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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A | ||
| Ligand | BDBM50259918 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1691999 | ||
| IC50 | 18000±n/a nM | ||
| Citation |  Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 55283.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P46098 | ||
| Residue: | 478 | ||
| Sequence: |
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| BDBM50259918 | |||
| n/a | |||
| Name | BDBM50259918 | ||
| Synonyms: | CHEMBL4105038 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H18ClN5S | ||
| Mol. Mass. | 347.866 | ||
| SMILES | Clc1ccc2nc(NC3=NCC4(CN5CCC4CC5)N3)sc2c1 |t:8,THB:19:11:14.15:17.18,(39.26,-19.74,;37.93,-20.51,;37.93,-22.06,;36.6,-22.83,;35.27,-22.06,;33.8,-22.54,;32.9,-21.3,;31.35,-21.3,;30.58,-22.63,;31.2,-24.04,;30.06,-25.07,;28.73,-24.3,;28.52,-25.68,;26.6,-24.87,;25.2,-25.8,;25.54,-24.41,;27.24,-23.65,;27.18,-22.01,;26.59,-23.4,;29.05,-22.79,;33.8,-20.04,;35.27,-20.52,;36.6,-19.75,)| | ||
| Structure | 
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