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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Ligand | BDBM50259925 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1691998 | ||
| EC50 | 140±n/a nM | ||
| Citation |  Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-7 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ||
| Type: | n/a | ||
| Mol. Mass.: | 56448.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHRNA7 (NACHRA7) | ||
| Residue: | 502 | ||
| Sequence: |
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| BDBM50259925 | |||
| n/a | |||
| Name | BDBM50259925 | ||
| Synonyms: | CHEMBL4077127 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H20N8 | ||
| Mol. Mass. | 324.3836 | ||
| SMILES | C1N=C(Nc2cc(ncn2)-n2ccnc2)NC11CN2CCC1CC2 |t:1,THB:15:16:19.20:22.23,(57.81,-6,;58.96,-4.97,;58.33,-3.56,;59.11,-2.23,;60.65,-2.23,;61.41,-3.57,;62.95,-3.57,;63.72,-2.23,;62.95,-.89,;61.41,-.9,;63.72,-4.9,;63.09,-6.31,;64.24,-7.34,;65.57,-6.57,;65.25,-5.07,;56.8,-3.72,;56.48,-5.23,;56.27,-6.61,;54.36,-5.81,;52.96,-6.73,;53.3,-5.34,;55,-4.59,;54.94,-2.95,;54.35,-4.34,)| | ||
| Structure | 
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