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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Ligand | BDBM50259945 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_1691998 | ||
| EC50 | 990±n/a nM | ||
| Citation |  Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-7 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Synonyms: | ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ||
| Type: | n/a | ||
| Mol. Mass.: | 56448.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHRNA7 (NACHRA7) | ||
| Residue: | 502 | ||
| Sequence: |
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| BDBM50259945 | |||
| n/a | |||
| Name | BDBM50259945 | ||
| Synonyms: | CHEMBL4093984 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C13H17ClN6 | ||
| Mol. Mass. | 292.767 | ||
| SMILES | Clc1cnc(NC2=NCC3(CN4CCC3CC4)N2)cn1 |t:6,THB:17:9:12.13:15.16,(39.13,-2.88,;37.59,-2.88,;36.81,-1.53,;35.27,-1.54,;34.51,-2.87,;32.97,-2.87,;32.19,-4.21,;32.82,-5.62,;31.67,-6.64,;30.34,-5.87,;30.13,-7.26,;28.21,-6.45,;26.81,-7.38,;27.16,-5.99,;28.85,-5.23,;28.79,-3.59,;28.2,-4.98,;30.66,-4.37,;35.27,-4.21,;36.81,-4.21,)| | ||
| Structure | 
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