| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock 70 kDa protein 1A |
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| Ligand | BDBM50260459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1693902 |
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| IC50 | >100000±n/a nM |
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| Citation |  Tillotson, J; Kedzior, M; Guimarães, L; Ross, AB; Peters, TL; Ambrose, AJ; Schmidlin, CJ; Zhang, DD; Costa-Lotufo, LV; Rodríguez, AD; Schatz, JH; Chapman, E ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett27:4082-4085 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock 70 kDa protein 1A |
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| Name: | Heat shock 70 kDa protein 1A |
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| Synonyms: | HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70 |
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| Type: | Chaperone |
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| Mol. Mass.: | 70043.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 641 |
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| Sequence: | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
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| BDBM50260459 |
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| n/a |
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| Name | BDBM50260459 |
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| Synonyms: | CHEMBL4099907 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19BrO |
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| Mol. Mass. | 295.215 |
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| SMILES | C[C@H]1C(=C)CC[C@@]1(C)c1cc(Br)c(C)cc1O |r| |
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| Structure | 
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