| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
|---|
| Ligand | BDBM50010931 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_68517 |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Abraham, A; McGuire, JJ; Galivan, J; Nimec, Z; Kisliuk, RL; Gaumont, Y; Nair, MG Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. J Med Chem34:222-7 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Folylpolyglutamate synthase, mitochondrial |
|---|
| Name: | Folylpolyglutamate synthase, mitochondrial |
|---|
| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 64621.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_68676 |
|---|
| Residue: | 587 |
|---|
| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
|
|
|
|---|
| BDBM50010931 |
|---|
| n/a |
|---|
| Name | BDBM50010931 |
|---|
| Synonyms: | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-3-hydroxy-pentanedioic acid | CHEMBL73267 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N7O6 |
|---|
| Mol. Mass. | 455.424 |
|---|
| SMILES | Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(C(O)CC(O)=O)C(O)=O)cnc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
