Reaction Details |
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Target | Folylpolyglutamate synthase, mitochondrial |
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Ligand | BDBM50010928 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_68517 |
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IC50 | 118000±n/a nM |
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Citation | Abraham, A; McGuire, JJ; Galivan, J; Nimec, Z; Kisliuk, RL; Gaumont, Y; Nair, MG Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. J Med Chem34:222-7 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Folylpolyglutamate synthase, mitochondrial |
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Name: | Folylpolyglutamate synthase, mitochondrial |
Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
Type: | PROTEIN |
Mol. Mass.: | 64621.95 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_68676 |
Residue: | 587 |
Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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BDBM50010928 |
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n/a |
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Name | BDBM50010928 |
Synonyms: | 2-{4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoylamino}-4-methylene-pentanedioic acid | CHEMBL308279 |
Type | Small organic molecule |
Emp. Form. | C23H25N7O5 |
Mol. Mass. | 479.4885 |
SMILES | CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CC(=C)C(O)=O)C(O)=O |
Structure |
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