| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
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| Ligand | BDBM50263159 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1697666 |
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| IC50 | 1060±n/a nM |
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| Citation |  Hofmans, S; Devisscher, L; Martens, S; Van Rompaey, D; Goossens, K; Divert, T; Nerinckx, W; Takahashi, N; De Winter, H; Van Der Veken, P; Goossens, V; Vandenabeele, P; Augustyns, K Tozasertib Analogues as Inhibitors of Necroptotic Cell Death. J Med Chem61:1895-1920 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 1 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
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| Synonyms: | Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74852.62 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116773 |
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| Residue: | 656 |
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| Sequence: | MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVL
LEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIV
EAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVS
STTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVI
CIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEE
DVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSS
SPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFA
QQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYP
PNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGL
NSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEI
DHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
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| BDBM50263159 |
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| n/a |
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| Name | BDBM50263159 |
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| Synonyms: | CHEMBL4065014 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N9O2 |
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| Mol. Mass. | 435.4823 |
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| SMILES | Cc1cc(Nc2nc(Nc3ccc(NC(=O)C4CC4)cc3)nc(n2)N2CCOCC2)n[nH]1 |
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| Structure | 
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