| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50406474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195778 |
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| IC50 | 0.310000±n/a nM |
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| Citation |  Thaisrivongs, S; Pals, DT; DuCharme, DW; Turner, SR; DeGraaf, GL; Lawson, JA; Couch, SJ; Williams, MV Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys. J Med Chem34:633-42 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50406474 |
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| n/a |
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| Name | BDBM50406474 |
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| Synonyms: | CHEMBL2028945 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H85N10O12S |
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| Mol. Mass. | 1122.399 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](CC(O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCCC(=O)N(C)CCS([O-])(=O)=O)C(C)C)C(=O)NCc1cccc[n+]1[O-] |r| |
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| Structure | 
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