| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
|---|
| Ligand | BDBM50265561 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1700087 (CHEMBL4051069) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Ito, M; Tanaka, T; Cary, DR; Iwatani-Yoshihara, M; Kamada, Y; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem60:3335-3351 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Eukaryotic initiation factor 4A-I |
|---|
| Name: | Eukaryotic initiation factor 4A-I |
|---|
| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46146.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_864983 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
|
|
|
|---|
| BDBM50265561 |
|---|
| n/a |
|---|
| Name | BDBM50265561 |
|---|
| Synonyms: | CHEMBL4073833 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H23BrClN5O2 |
|---|
| Mol. Mass. | 588.882 |
|---|
| SMILES | Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
