Reaction Details |
| Report a problem with these data |
Target | Eukaryotic initiation factor 4A-III |
---|
Ligand | BDBM50265568 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1700084 (CHEMBL4051066) |
---|
IC50 | 1100±n/a nM |
---|
Citation | Ito, M; Tanaka, T; Cary, DR; Iwatani-Yoshihara, M; Kamada, Y; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem60:3335-3351 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Eukaryotic initiation factor 4A-III |
---|
Name: | Eukaryotic initiation factor 4A-III |
Synonyms: | ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265 |
Type: | Protein |
Mol. Mass.: | 46871.02 |
Organism: | Homo sapiens (Human) |
Description: | P38919 |
Residue: | 411 |
Sequence: | MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
|
|
|
BDBM50265568 |
---|
n/a |
---|
Name | BDBM50265568 |
Synonyms: | CHEMBL4080496 |
Type | Small organic molecule |
Emp. Form. | C25H20Cl2N4O2 |
Mol. Mass. | 479.358 |
SMILES | Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnn2ccccc12 |
Structure |
|