Reaction Details | |||
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Target | Protein Mdm4 | ||
Ligand | BDBM50266879 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1701466 (CHEMBL4052448) | ||
Ki | 14700±n/a nM | ||
Citation | Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem60:4234-4244 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Mdm4 | |||
Name: | Protein Mdm4 | ||
Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 54842.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
Residue: | 490 | ||
Sequence: |
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BDBM50266879 | |||
n/a | |||
Name | BDBM50266879 | ||
Synonyms: | CHEMBL4072678 | ||
Type | Small organic molecule | ||
Emp. Form. | C33H23Cl2FN4O3 | ||
Mol. Mass. | 613.465 | ||
SMILES | OC(=O)c1ccc(CNC(=O)c2[nH]c3cc(Cl)ccc3c2-c2c(ncn2Cc2ccc(Cl)cc2)-c2ccc(F)cc2)cc1 |(10.42,-22.35,;11.96,-22.35,;12.74,-23.68,;12.72,-21.02,;11.95,-19.68,;12.71,-18.35,;14.25,-18.34,;15.01,-17.01,;16.55,-17,;17.32,-15.67,;16.54,-14.33,;18.85,-15.66,;19.75,-16.91,;21.21,-16.42,;22.56,-17.17,;23.87,-16.4,;25.21,-17.16,;23.86,-14.86,;22.54,-14.1,;21.21,-14.89,;19.75,-14.4,;19.27,-12.95,;20.17,-11.7,;19.26,-10.47,;17.8,-10.94,;17.8,-12.48,;16.57,-13.39,;15.17,-12.77,;13.93,-13.69,;12.51,-13.07,;12.35,-11.54,;10.95,-10.91,;13.58,-10.63,;15,-11.24,;21.71,-11.7,;22.46,-10.36,;24,-10.35,;24.77,-11.69,;26.31,-11.67,;24.01,-13.01,;22.47,-13.03,;15.02,-19.67,;14.26,-21.01,)| | ||
Structure |