Reaction Details | |||
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Target | Protein Mdm4 | ||
Ligand | BDBM50266881 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1701466 (CHEMBL4052448) | ||
Ki | 27400±n/a nM | ||
Citation | Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem60:4234-4244 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Mdm4 | |||
Name: | Protein Mdm4 | ||
Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 54842.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
Residue: | 490 | ||
Sequence: |
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BDBM50266881 | |||
n/a | |||
Name | BDBM50266881 | ||
Synonyms: | CHEMBL4094325 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H30Cl2FN5O | ||
Mol. Mass. | 578.507 | ||
SMILES | CCN(CC)CCNC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(14.1,-21.32,;15.64,-21.32,;16.41,-22.65,;15.64,-23.99,;16.41,-25.32,;17.95,-22.65,;18.71,-21.32,;20.25,-21.32,;21.02,-19.99,;20.25,-18.65,;22.56,-19.99,;23.47,-21.23,;24.93,-20.76,;26.27,-21.53,;27.6,-20.76,;28.94,-21.53,;27.6,-19.22,;26.27,-18.45,;24.93,-19.22,;23.47,-18.74,;22.99,-17.27,;23.89,-16.02,;22.99,-14.78,;21.53,-15.25,;21.53,-16.79,;20.28,-17.71,;18.87,-17.08,;17.63,-17.98,;16.22,-17.36,;16.06,-15.82,;14.66,-15.2,;17.31,-14.92,;18.72,-15.54,;25.43,-16.02,;26.2,-14.69,;27.74,-14.69,;28.51,-16.02,;30.05,-16.02,;27.74,-17.36,;26.2,-17.36,)| | ||
Structure |