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Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein Mdm4 | ||
| Ligand | BDBM50266884 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1701466 (CHEMBL4052448) | ||
| Ki | 35300±n/a nM | ||
| Citation |  Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem60:4234-4244 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein Mdm4 | |||
| Name: | Protein Mdm4 | ||
| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
| Type: | Oncoprotein | ||
| Mol. Mass.: | 54842.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
| Residue: | 490 | ||
| Sequence: |
| ||
| BDBM50266884 | |||
| n/a | |||
| Name | BDBM50266884 | ||
| Synonyms: | CHEMBL4084081 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C34H32Cl2FN5O2 | ||
| Mol. Mass. | 632.555 | ||
| SMILES | Fc1ccc(cc1)-c1ncn(Cc2ccc(Cl)cc2)c1-c1c([nH]c2cc(Cl)ccc12)C(=O)N1CCC(CC1)N1CCOCC1 |(30,-14.56,;28.46,-14.56,;27.69,-13.23,;26.15,-13.23,;25.38,-14.56,;26.15,-15.9,;27.69,-15.9,;23.84,-14.56,;22.94,-13.32,;21.47,-13.79,;21.47,-15.33,;20.22,-16.24,;18.82,-15.61,;17.57,-16.52,;16.17,-15.9,;16.01,-14.36,;14.6,-13.73,;17.25,-13.46,;18.66,-14.08,;22.94,-15.81,;23.41,-17.27,;22.51,-18.52,;23.41,-19.77,;24.88,-19.29,;26.21,-20.06,;27.55,-19.29,;28.88,-20.06,;27.55,-17.75,;26.21,-16.98,;24.88,-17.75,;20.97,-18.52,;20.2,-17.19,;20.2,-19.85,;20.97,-21.19,;20.2,-22.52,;18.66,-22.52,;17.89,-21.19,;18.66,-19.85,;17.89,-23.85,;18.66,-25.19,;17.89,-26.52,;16.35,-26.52,;15.58,-25.19,;16.35,-23.85,)| | ||
| Structure | 
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