| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50269282 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1705795 (CHEMBL4057028) |
|---|
| EC50 | 0.022200±n/a nM |
|---|
| Citation |  Suzuki, S; Sugawara, Y; Tsuji, R; Tanimura, R; Kaneko, C; Yuzawa, N; Yagi, M; Kawai, K Discovery of highly selective?-opioid receptor agonists: 10?-Hydroxy TRK-820 derivatives. Bioorg Med Chem Lett27:3920-3924 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42648.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41145 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
|
|
|
|---|
| BDBM50269282 |
|---|
| n/a |
|---|
| Name | BDBM50269282 |
|---|
| Synonyms: | CHEMBL4082823 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H34N2O5 |
|---|
| Mol. Mass. | 502.6014 |
|---|
| SMILES | [H][C@@]12Oc3c4c(ccc3O)[C@H](O)[C@@]3([H])N(CC5CC5)CC[C@@]14[C@@]3(O)CC[C@H]2N(C)C(=O)\C=C\c1ccccc1 |r,THB:15:14:22:4.5.10| |
|---|
| Structure | 
|
|---|
Search and Browse
