| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Ligand | BDBM50012900 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_3961 |
|---|
| IC50 | 13000±n/a nM |
|---|
| Citation |  Flynn, DL; Capiris, T; Cetenko, WJ; Connor, DT; Dyer, RD; Kostlan, CR; Nies, DE; Schrier, DJ; Sircar, JC Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem33:2070-2 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 78082.31 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1432947 |
|---|
| Residue: | 673 |
|---|
| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
|
|
|
|---|
| BDBM50012900 |
|---|
| n/a |
|---|
| Name | BDBM50012900 |
|---|
| Synonyms: | 2-[6-Fluoro-3-(4-methanesulfinyl-benzylidene)-2-methyl-3H-inden-1-yl]-N-hydroxy-acetamide | CHEMBL65299 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18FNO3S |
|---|
| Mol. Mass. | 371.425 |
|---|
| SMILES | CC1=C(CC(=O)NO)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O |c:1| |
|---|
| Structure | 
|
|---|
Search and Browse
