| Reaction Details |
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 | Report a problem with these data |
| Target | Urotensin-2 receptor |
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| Ligand | BDBM50269957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1707628 (CHEMBL4058861) |
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| EC50 | 1.4±n/a nM |
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| Citation |  Douchez, A; Billard, E; Hébert, TE; Chatenet, D; Lubell, WD Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics. J Med Chem60:9838-9859 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urotensin-2 receptor |
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| Name: | Urotensin-2 receptor |
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| Synonyms: | G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42725.34 |
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| Organism: | RAT |
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| Description: | Urotensin-II UTS2R RAT::P49684 |
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| Residue: | 386 |
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| Sequence: | MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA
MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD
VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL
TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL
SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY
LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG
RSLSSSSQQATETLMLSPVPRNGALL
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| BDBM50269957 |
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| n/a |
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| Name | BDBM50269957 |
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| Synonyms: | CHEMBL4068478 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H32ClN5OS |
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| Mol. Mass. | 582.158 |
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| SMILES | Cl.NCCCN1N=C(CCc2nc3ccccc3s2)c2ccccc2N(Cc2ccc(cc2)-c2ccccc2)C1=O |t:5| |
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| Structure | 
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