| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50210810 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208027 |
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| IC50 | 150±n/a nM |
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| Citation |  Hildebrand, C; Sandoli, D; Focher, F; Gambino, J; Ciarrocchi, G; Spadari, S; Wright, G Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases. J Med Chem33:203-6 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1 | TK | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40902.47 |
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| Organism: | Human herpesvirus 1 |
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| Description: | ChEMBL_208027 |
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| Residue: | 376 |
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| Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
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| BDBM50210810 |
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| n/a |
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| Name | BDBM50210810 |
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| Synonyms: | 2-(3-Trifluoromethyl-phenylamino)-1,9-dihydro-purin-6-one | CHEMBL405761 | N2-(3-trifluoromethylphenyl)guanine |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8F3N5O |
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| Mol. Mass. | 295.22 |
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| SMILES | FC(F)(F)c1cccc(Nc2nc3nc[nH]c3c(=O)[nH]2)c1 |
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| Structure | 
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